The Best Hypoallergenic Pillowcases to Solve Your Sleep Struggles

The best hypoallergenic pillowcases might be closer than you think. Fabrics like silk, linen, bamboo, and lyocell (made from wood pulp) are naturally hypoallergenic and excellent for allergy sufferers. 

There’s also the option to choose fabrics with silver woven in. Silver is often used to keep you cooler and drier at night, but it can also be antimicrobial and hypoallergenic.

From there, you can look at other features they offer (like zippers, colors, patterns, or whether they’re available as singles, doubles, or only part of a whole sheet set) to make your decision.

If you thought you were stuck with a stodgy old white pillowcase because of your allergies or asthma, you’re in luck. There are so many hypoallergenic pillowcase possibilities once you dive in and start looking at naturally hypoallergenic fabrics. 

The Best Hypoallergenic Pillowcases: Quick Take

• Best overall: Miracle Brand Antimicrobial Silk Pillowcase
• Best silver-lined: Miracle Brand Antimicrobial Silk Pillowcase
• Best bamboo: Cozy Earth Bamboo Pillowcases or Bearaby Second Skin Sheets (if you need a whole sheet set)
• Best linen: Cultiver Linen Pillowcases or Piglet in Bed 100% Linen Pillowcase
• Best silk: Blissy Silk Pillowcase
• Best lyocell: Sheex Arctic Aire MAX Pillowcases
• Most affordable: THX Silk Pillowcase or Mission Allergy Pillow Encasing (for severe allergies)

What to Look for in a Hypoallergenic Pillowcase

There are several routes you can take when you’re looking for the best hypoallergenic pillowcases to suit your needs. Lots of fabrics are hypoallergenic, so once you narrow those down, you’ll be looking at what other benefits you want from your pillowcase. 

• Do you want something that’s gentle on hair and skin, for anti-aging or anti-acne benefits, and to prevent hair breakage as you sleep? Let silk be your first choice.
• Do you want something that keeps you cool (you’ll still have a few options)? Breathable materials and silver will be perfect.
• Looking for a set of sheets that stays clean longer so you don’t have to do laundry as often, but you get to feel fresh night after night when you sleep into bed? Again, silver.
• What’s your budget? A range of price points is available in hypoallergenic options. 
• Are you a fan of natural fibers, and that’s really all you want from your bedding, beyond it being hypoallergenic? You’ll have plenty of options to choose from.
• Do you have severe allergies you’re trying to mitigate? You might want to choose one with a zipper.

By searching for a hypoallergenic pillowcase option, you’re opening up a sea of possibilities that can change other parts of your sleep life, as well. 

The 18 Best Hypoallergenic Pillowcases 

Here are 18–well, 18.5 if you consider Cultiver’s Flip option as a separate selection (keep reading to see what we mean)–of the best hypoallergenic pillowcases on the market. These top picks include silk, linen, bamboo, Lyocell, and silver-woven fabrics.

Miracle Brand Antimicrobial Silk Pillowcase 

Because silk is naturally hypoallergenic and Miracle Brand uses silver in their sheets, the Miracle Brand Antimicrobial Silk Pillowcase is a double-whammy option worthy of a top spot on the list. It comes in Standard or King, and is available in Sky Blue, Ivory, and Silver Grey.

Beyond the hypoallergenic nature, this pillowcase will feel cooler than average, thanks to the silver woven into the fabric. Plus, the silk will be gentler on your hair and skin than other fabrics. 

Downside: Price. Expect to pay between $60 and $70 for a single pillowcase. Also, they seem to sell out a lot, so getting your hands on one–and one on your pillow–could prove challenging. 

THX Silk Pillowcase

The THX Silk Pillowcase is available in 19, 22, 25, and 30 Momme (similar to thread count; higher numbers mean denser, more durable fabric) options and comes in four sizes and about 15 colors (not all pillowcase options come in all colors, however). 

There are even some patterned options, like one with Van Gogh’s famous Starry Night painting, and Monet’s Water Lilies. THX stands out for its variety. You can even find pillowcases for contour and cervical pillows, as well as body pillows. 

Prices start around $28.00, making this one of the more affordable options on the list.    

AllerEase 

AllerEase pillowcases are basic in looks (only available in white), but they’re available in Standard/Queen and King sizes and, if you have Prime, easy to get your hands on quickly. 

Though made of polyester, they claim to help regulate temperature–making you feel cooler when you’re hot, and hotter when it’s cool. 

The allergy help comes in the form of densely woven fabric that keeps common allergens from making their way into your pillow. They’re also resistant to bacterial growth, which can help keep allergens and allergies at bay.  

Mission Allergy

Mission Allergy pillow covers aren’t pillow “cases,” per se, but instead hold your pillow inside a zipped microfiber polyester cover, inside your regular pillowcase (so you don’t necessarily need to swap out all your sheets to enjoy the benefits of a hypoallergenic option). They keep allergens from escaping to aggravate your allergies, asthma, or skin.

If your allergies are especially awful, they also offer encasings for your mattress and box spring that might be worth a look.

Prices for the pillow encasings start just under $30.00.  

Blissy Silk Pillowcases

Blissy Silk Pillowcases do double-duty. They protect you from allergens, and they’re great for beauty because they’re easy on your hair and skin (as silk always is!). And just like a lot of options on this list, this fabric will help keep you cool while you sleep, too.

The zipper keeps allergens firmly tucked away, so you’re not exposed to dust mites in your pillow, and due to the moisture-resistant nature of silk, your pillow and pillowcase will be less likely to harbor mold or mildew, which could exacerbate asthma, allergies, and skin issues.  

These come in Toddler, Youth, Standard, Queen, and King sizes, and a wide range of colors and patterns. 

As of this writing, the regular price for a Standard size is around $100.00, but keep your eyes peeled for sales, especially around Black Friday.  

EverCool Cooling Pillowcases

Here’s another silver-infused option that keeps you cool (they’re cool-to-the-touch!) and helps minimize allergens at the same time. 

You can get them in six colors and choose between Standard and King sizes. Prices start at just under $80.00 for a set of two pillowcases.

Bearaby Second Skin Pillowcases

Bearaby Second Skin Sheets include pillowcases made from bamboo that keep you cool, and have an extra superpower: mint (don’t worry, there’s no minty smell). Bamboo sheets are less attractive to allergens.

The mint works similarly to the silver in other pillowcases on the list–it’s woven in and meant to fight germs and bacteria. Less of those means fewer dust mites that want to feed on them… and fewer allergens. 

You’ll have to buy a whole set of sheets to get the pillowcases, as of this writing (no pillowcases are listed separately on their site), but if that’s what you’re looking for, these are worth a look. 

Expect to pay between $200.00 and $300.00, depending on the size you need. The price is definitely a drawback.

Silvon Mulberry Silk Pillowcase

The Silvon Mulberry Silk Pillowcase is a bit of an odd option, but it could be perfect for the person just looking for a simple hypoallergenic pillowcase (Standard or King) and nothing else. If you want matching sheets or fun colors (these only come in white), you’ll be out of luck, but there’s a matching duvet option. 

It’s mulberry silk, woven with silver. These are just over $50.00 and made to help regulate your temperature as you sleep and help your skin and hair look great.  

Sheex Arctic Aire MAX Pillowcases

Sheex Arctic Aire MAX Pillowcases are made from TENCEL™ Lyocell, another naturally hypoallergenic option that keeps you cool through the night. Expect to pay $60.00 or less for a set of two Standard pillowcases. 

You can get them in Standard or King sizes, in five different colors. They’re available in sets of two, or you can grab a whole set of Arctic Aire MAX sheets in Queen, King, or Cali King (the regular price starts around $250.00, but be on the lookout for sales). 

Slip Silk Pillowcases

Slip pillowcases are available in nearly 30 colors and patterns, and they zip to keep allergens in your pillow from making your night miserable. They’re silk, so they’re easy on your hair and can help prevent wrinkles on your skin.

Slip pillowcases are available in Standard, Queen, and King sizes. Though lovely, these aren’t cheap! Prices start around $115.00.  

Dosaze 100% Mulberry Silk Pillowcase

Dosaze 100% Mulberry Silk Pillowcases are regularly just under $200.00, but they come with a 60-day trial and a three-year warranty. They combine silk for antimicrobial and hypoallergenic effects, plus silver for more of those same benefits (as well as anti-acne). 

The silk, again, will be especially kind to hair and skin while discouraging allergens from causing any skin or respiratory issues.

These are available in King or Queen, in Soft Grey, Ivory, Deep Navy, and Snow White.

Cultiver Linen Pillowcases

Cultiver Linen Pillowcases are usually priced at just under $100.00 for two, and you can get them in almost 20 different colors. Grab a set in Standard or King. 

They’re made from linen (from European flax) and designed to feel like the epitome of cozy comfort from the moment you take them out of the package. 

If you love the idea of a pillowcase that brings variety not based on the colors and patterns it comes in, you might love their (also hypoallergenic) Silk Linen Flip Pillowcase, which is the regular linen on one side and mulberry silk on the other.

Under the Canopy TENCEL Lyocell Pillowcase

The Under the Canopy TENCEL Lyocell Pillowcase is only available in two colors (Forest and White), in Standard and King sizes, but you can get two for less than $40.00. 

These are biodegradable, compostable pillows made from eucalyptus. This type of fabric helps keep you cool at night.

Washing them will take a bit more care than some of the other options. Wash inside-out on gentle (or wool cycle, if you have one), then line dry if you can, or dry on low if you can’t.

Cozy Earth Bamboo Pillowcases

Cozy Earth Bamboo Pillowcases are available in Standard, King, and Body sizes, and they look luxurious. You can choose from 14 regular colors and patterns, plus, depending on when you shop, a limited edition selection, too. 

Prices start at $78.00 for two Standard pillowcases. When you order a Body pillowcase, you only get one.

Cozy Earth Silk Pillowcase

There’s another Cozy Earth pillowcase to consider: silk. There are 12 colors available (all neutral or neutral-adjacent), and you can pick them up in Standard or King sizes. If you really prefer wash-and-dry laundry loads that don’t require extra thought, keep in mind that this silk version cannot go in the dryer. 

You can get one pillowcase for just under $80.00 (be on the lookout for sales, though). There’s a chance you can use your HSA/FSA account to cover it, though.

Piglet in Bed 100% Linen Pillowcase 

The Piglet in Bed 100% Linen Pillowcase is made from European flax, available in about 25 colors and patterns, and you can get it in Standard, Queen, King, and, for a limited time, Square sizes. 

Pricing starts at just under $90.00 for the 100 percent linen option.

While there’s no zipper, these have envelope closures to keep your pillow more tucked away than your average pillowcase.  

Ettitude Luxe Bamboo Pillowcase 

The Ettitude Luxe Bamboo Pillowcase is made with what they call PLNTsilk™ weave, made from Bamboo Lyocell and Bamboo Biochar. 

In addition to being hypoallergenic, it’s antimicrobial, it’s anti-odor, and antifungal. Like many of the other options on the list, the Ettitude Luxe Bamboo Pillowcase will keep you cooler than your average pillowcase, and it’s a pro at wicking moisture away so you stay dry.

This option is $120.00 for a set of two pillowcases.  

Miracle Brand Pillow Cases (Original or Extra Luxe)

Miracle Brand’s other pillowcases, available in Original and Extra Luxe (which feels a few degrees cooler than the original), are also antimicrobial, thanks to strands of silver woven right into the 100 percent cotton fabric, and can reduce allergens. 

These are worth mentioning because of their antimicrobial properties from the silver, which in turn cuts down on dust mites, but they aren’t specifically listed as hypoallergenic.

These come as part of larger sheet sets, or they can be purchased individually, in Standard and King sizes. You’ll have your pick of over 10 colors.

Which Hypoallergenic Pillowcase Is Right for You?

The best hypoallergenic pillowcase for you will depend on what else you’re looking for in a pillow. Luckily, most of the naturally hypoallergenic fabrics help keep you from overheating through the night, and then some have extra help, like silver, to do an even better job of keeping you cool and dry, and your pillow as free from bacteria and mold as possible. 

If anti-aging and hair health are your secondary concerns after allergies, you’ll want a silk pillowcase (there are several, so you still have plenty of options!). Need help staying cool? Look for a silk pillowcase with silver woven through the fabric. 

Someone with severe allergies and asthma may specifically need an option that encases the whole pillow and zips closed, while someone with milder allergies could have their pick of the whole list and be satisfied with the results.  

Though most options on the list would be considered a splurge for pillowcases, many offer extended trial periods, so you can see which one helps you the most without much risk. You may need to try a few before you find your perfect hypoallergenic pillowcase, but you won’t be stuck with a stack of sheets you can’t use.